IκB kinase (IKK)
The IκBs form a small family of related proteins with a core consisting of six or more ankyrin repeats, an N-terminal regulatory domain and a C-terminal domain that contains a PEST motif. There is strong biochemical and genetic evidence that the IKK complex, which consists of two catalytic subunits, IKKα and IKKβ, and a regulatory subunit, IKKγ, is the master regulator of NF-κB-mediated innate immune and inflammatory responses. The best-studied and major IκB protein is IκBα.IκB kinase activity is essential for activation of members of the nuclear factor-kB (NF-κB) family of transcription factors, which play a fundamental role in lymphocyte immunoregulation. Increased NF-κB activity as a result of constitutive IKK-mediated phosphorylation of IκBα has been observed in the development of atherosclerosis, asthma, rheumatoid arthritis, inflammatory bowel diseases, and multiple sclerosis.
Amino Acids and Derivatives(26) Antiviral(18) CD110(2) Cell wall(2) Complement System(16) FLAP(7) Hydroxylase(6) Interferon Receptor(2) IRAK(13) IκB kinase (IKK)(32) Lipoxygenase(13) LTR(5) MyD88(3) NOS(34) PD-1/PD-L1(13) PGE synthase(11) RLR(4) ROS(23) Scavenger Receptor(2) SphK(3) STING(9) TLR(23)