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Leukotriene Receptor

The leukotriene receptors are activated by the endogenous ligands leukotrienes (LT), synthesized from lipoxygenase metabolism of arachidonic acid. The leukotriene (LT) receptors are G protein-coupled receptors that bind and are activated by the leukotrienes. They include the following proteins:BLT1 (Leukotriene B4 receptor 1) ,BLT2 (Leukotriene B4 receptor 2) ,CysLT1 (Cysteinyl leukotriene receptor 1) ,CysLT2 (Cysteinyl leukotriene receptor 2) .BLT1 had been considered as an important drug target, especially for inflammatory diseases. Here we describe representative reports on animal disease models using BLT1-knockout (BLT1-KO) mice and BLT1 antagonists.BLT2 agonists are attracting interest as new drugs for skin, corneal, and intestinal ulcers.

References

1.Takehiko Yokomizo et al.J Clin Invest. 2018 Jul 2; 128(7): 2691–2701.