Aromatase is the sole member of family 19 of the P450 superfamily of enzymes, termed CYP19. Aromatase is a microsomal protein that is found throughout the vertebrate phylum, but the human gene is unique compared with the rest of its superfamily.The aromatase reaction employs 3 moles of oxygen and 3 moles of NADPH for every mole of steroid substrate metabolized. Aromatase shares a number of structural features common to all cytochrome P450 species.Aromatase is most widely known for its roles in reproduction and reproductive system diseases, and as a target for inhibitor therapy in estrogen-sensitive diseases including cancer, endometriosis, and leiomyoma.


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