Cytoplasmic dynein-1 (hereafter, dynein) is a large protein complex that drives long-range retrograde transport along microtubules.It carries a broad range of cargos, from mRNAs to entire organelles and plays a key role in cellular processes as diverse as fast axonal transport, Golgi dynamics and mitosis. Structurally, dynein consists of a motor domain that produces mechanical motion and a tail domain that is important for cargo binding, regulation and homodimerisation. Dynein works together with another large protein complex called dynactin which is required for virtually all known dynein functions.


1.Carter AP,et al. Curr Opin Struct Biol. 2016 Apr;37:62-70.