LIM Kinase (LIMK)

There are two human LIM-kinases, each containing two N terminal LIM domains, a central PDZ domain, and a C-terminal Ser/Thr protein kinase domain. Hemizygous deletion of LIM-kinase is implicated in the neurological manifestations of Williams syndrome.LIM kinase may also play a role in the photoreceptor response to injury in the form of neuritic process outgrowth. LIM kinase is well known to function in regulating actin polymerization in cooperation with the pathways that promote nucleation and extension of new actin filament branches.LIM kinase inhibition may have therapeutic potential for reducing pathologic rod terminal plasticity after retinal injury.


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